
The Binding of Isaac: Rebirth
The Binding of Isaac: Rebirth is Edmund McMillen's roguelike twin-stick shooter, published by Nicalis on 4 November 2014. Isaac flees his mother into the basement and fights his way down with his own tears. Four expansions followed (Afterbirth, Afterbirth+, Repentance and Repentance+), and together they took the item count past 700.
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Overview
Where an item can drop matters as much as what it does. Brimstone only rolls from the Devil Room pools and the Ultra Secret Room, and Sacred Heart sits in the Angel Room pools, so which room you reach decides which half of the item list you're fishing in. Quality runs from 0 to 4, and only 40 items reach the top grade. Twelve of the 14 transformations are built from items that share a tag, with Guppy's set at 7 and Conjoined's at 31. A new save file is thin. Of the 719 items, 273 stay locked until you earn the achievement tied to them, and Dead God only pops once the other 636 achievements are done.
Explore The Binding of Isaac: Rebirth Guides

Quality, item pools, charge and pickup quote for all 719 collectibles.

Every trinket's pickup quote, expansion and unlock.

Tarot, reversed tarot, playing cards, runes and soul stones.
All 50 pill effects, sorted into good, bad and neutral.

Starting health, items and Birthright, tainted characters included.

Which items count toward Guppy, Beelzebub and the rest.

Boss HP and the floors each one can show up on.

HP and contact damage for every monster in the in-game Bestiary.

Every floor and alternate floor, with its boss pool.

Character, starting items, goal and reward for all 45 challenges.

All 637 achievements and what they unlock, with a Dead God tracker.

All 563 co-op and special babies, and which need unlocking.
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