Challenges
All 45 challenges: character, loadout, goal and reward
Data updated
Overview
Eight challenges pay out a rune. Pitch Black, High Brow and Head Trauma all start you as Isaac with Depths II as the goal, and reward Hagalaz, Jera and Ehwaz. Others push further. Darkness Falls puts you in Eve's shoes until Sheol or the Cathedral, and Suicide King does the same with Lazarus. Only 11 of the 45 are open from the start. The rest need an achievement first.
#1Pitch Black
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Reward
- Rune of Hagalaz
#2High Brow
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Butt Bombs, Number One, E. Coli, Flush!
- Trinkets
- Petrified Poop
- Reward
- Rune of Jera
#3Head Trauma
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Tiny Planet, Soy Milk, Iron Bar, The Small Rock
- Reward
- Rune of Ehwaz
#4Darkness Falls
Locked until you earn its unlock
- Character
- Eve
- Goal
- Sheol
- Needs
- Eve, It Lives!, Sacrificial Dagger
- Items
- Razor Blade, Dark Matter, Pentagram, Sacrificial Dagger
- Reward
- Rune of Dagaz
#5The Tank
Locked until you earn its unlock
- Character
- Magdalene
- Goal
- Depths II
- Needs
- Magdalene
- Items
- Thunder Thighs, Bucket of Lard, Infamy
- Reward
- Rune of Ansuz
#6Solar System
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- A Noose
- Items
- Distant Admiration, Forever alone, Halo of Flies, Transcendence
- Tears
- Can’t fire tears
- Reward
- Rune of Perthro
#7Suicide King
Locked until you earn its unlock
- Character
- Lazarus
- Goal
- Cathedral
- Needs
- Lazarus, It Lives!
- Items
- Ipecac, My Reflection, Mr. Mega
- Reward
- Rune of Berkano
#8Cat Got Your Tongue
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Depths II
- Needs
- Guppy's Hairball
- Items
- Guppy's Tail, Guppy's Head, Guppy's Hairball
- Tears
- Can’t fire tears
- Reward
- Rune of Algiz
#9Demo Man
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- A Fetus in a Jar
- Items
- Dr. Fetus, Remote Detonator
- Trinkets
- Match Stick
- Reward
- Chaos Card
#10Cursed!
Locked until you earn its unlock
- Character
- Magdalene
- Goal
- Depths II
- Needs
- Magdalene
- Items
- Treasure Map, The Compass, Blue Map, Raw Liver
- Trinkets
- Child's Heart
- Reward
- Credit Card
#11Glass Cannon
Locked until you earn its unlock
- Character
- Judas
- Goal
- Sheol
- Needs
- Loki's Horns, Epic Fetus, It Lives!, Judas
- Items
- Epic Fetus, Loki's Horns
- Reward
- Rules Card
#12When Life Gives You Lemons
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Lemon Mishap, Habit, 9 Volt
- Pill
- Lemon Party
- Reward
- Card Against Humanity
#13BEANS!
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Butt Bombs, Pyro, The Black Bean, The Bean, 9 Volt
- Tears
- Can’t fire tears
- Reward
- Burnt Penny
#14Its In The Cards
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Starter Deck, Deck of Cards, 9 Volt, The Battery
- Reward
- SMB Super Fan
#15Slow Roll
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Polyphemus, Cupid's Arrow, My Reflection
- Reward
- Swallowed Penny
#16Computer Savy
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Technology, Technology 2, Spoon Bender
- Reward
- Robo Baby 2.0
#17WAKA WAKA
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- Strange Attractor, Anti-Gravity
- Reward
- Death's Touch
#18The Host
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- The Mulligan, Spiderbaby
- Trinkets
- Tick
- Reward
- Technology .5
#19The Family Man
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Cathedral
- Needs
- It Lives!, Dad's Key
- Items
- Dad's Key, Sister Maggy, Brother Bobby, Rotten Baby, BFFS!
- Tears
- Can’t fire tears
- Reward
- Epic Fetus
#20Purist
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- The Womb
- Reward
- Missing No.
#21XXXXXXXXL
Locked until you earn its unlock
#22SPEED!
Locked until you earn its unlock
#23Blue Bomber
Locked until you earn its unlock
- Character
- ???
- Goal
- Sheol
- Needs
- Mr. Mega!, It Lives!
- Items
- Kamikaze!, Mr. Mega, Pyromaniac, Brother Bobby
- Tears
- Can’t fire tears
#24PAY TO PLAY
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Cathedral
- Needs
- Mr. Mega!, A Bag of Pennies
- Items
- Sack of Pennies, Money = Power
#25Have a heart
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- The Womb
- Items
- Charm of the Vampire
#26I RULE!
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Mega Satan
- Needs
- Mom's Knife, The Negative, Apollyon
- Items
- Mom's Knife, Trinity Shield, The Boomerang, The Ladder
#27BRAINS!
Locked until you earn its unlock
- Character
- ???
- Goal
- The Chest
- Needs
- The Polaroid
- Items
- Bob's Brain, Bob's Brain, Bob's Brain, Thunder Thighs
- Tears
- Can’t fire tears
#28PRIDE DAY!
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- The Womb
- Items
- Rainbow Baby, 3 Dollar Bill
- Trinkets
- Rainbow Worm
#29Onan's Streak
Locked until you earn its unlock
- Character
- Judas
- Goal
- Cathedral
- Needs
- It Lives!, Judas
- Items
- Chocolate Milk
#30The Guardian
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- The Womb
- Items
- Punching Bag, Isaac's Heart, Holy Grail, Spear Of Destiny
- Tears
- Can’t fire tears
#31Backasswards
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Mega Satan
- Needs
- The Negative, Apollyon
#32Aprils fool
Locked until you earn its unlock
#33Pokey mans
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Cathedral
- Needs
- It Lives!
- Items
- Mom's Eyeshadow, Friendly Ball
#34Ultra hard
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Mega Satan
- Needs
- The Negative, Apollyon
#35PONG
Locked until you earn its unlock
- Character
- Isaac
- Goal
- The Chest
- Needs
- The Polaroid
- Items
- Cupid's Arrow, Rubber Cement
#36Scat Man
Available from the start
- Character
- Isaac
- Goal
- Depths II
- Items
- 9 Volt, Skatole, The Poop, E. Coli, Butt Bombs, Butt Bombs, Butt Bombs, BFFS!, Thunder Thighs, Dirty Mind
- Trinkets
- Mysterious Candy
- Tears
- Can’t fire tears
#37Bloody Mary
Locked until you earn its unlock
- Character
- Bethany
- Goal
- Sheol
- Needs
- It Lives!, Blood Bag, Bethany
- Items
- The Book of Belial, Blood Bag, Anemic, Blood Oath
- Removed
- Book of Virtues
- Trinkets
- Child's Heart
#38Baptism by Fire
Locked until you earn its unlock
- Character
- Bethany
- Goal
- Cathedral
- Needs
- It Lives!, Maggy's Faith, Bethany, Urn of Souls
- Items
- Schoolbag, Guppy's Paw, Urn of Souls
- Removed
- Book of Virtues
- Trinkets
- Maggy's Faith
- Tears
- Can’t fire tears
#39Isaac's Awakening
Locked until you earn its unlock
- Character
- Isaac
- Goal
- Womb II
- Needs
- Jacob and Esau
- Items
- Spirit Sword, Mom's Bracelet, Trinity Shield
#40Seeing Double
Locked until you earn its unlock
- Character
- Jacob
- Goal
- Womb II
- Needs
- Jacob and Esau
- Items
- 20/20
#41Pica Run
Locked until you earn its unlock
#42Hot Potato
Locked until you earn its unlock
- Character
- Tainted Forgotten
- Goal
- Sheol
- Needs
- The Fettered
- Tears
- Can’t fire tears
#43Cantripped!
Locked until you earn its unlock
- Character
- Tainted Cain
- Goal
- Depths II
- Needs
- The Hoarder
#44Red Redemption
Locked until you earn its unlock
- Character
- Tainted Jacob
- Goal
- Womb II
- Needs
- The Deserter, Red Key
- Items
- Dad's Key
#45DELETE THIS
Locked until you earn its unlock
- Character
- Isaac
- Goal
- The Chest
- Needs
- The Capricious
- Items
- TMTRAINER
