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At 4 BSC cell drops triple and bosses get 70% extra health.
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Boss Stem Cells set the difficulty, and each one stacks on the last. 1 BSC gives bosses 10% more health and adds 5% more enemies. 2 BSC doubles cell drops and gives elites extra health. 3 BSC adds an elite per level. At 4 BSC cell drops triple, bosses carry 70% extra health and elites 60%, and enemies turn aggressive. 5 BSC keeps those numbers and makes the Malaise carry over from one biome to the next.
| Boss Stem Cells | Cell drops | Extra gear levels | Locked fountains | Extra elites per biome | Elite HP | Boss HP | Extra enemies | Other |
|---|---|---|---|---|---|---|---|---|
| 0 (Normal) | x1 | – | – | – | – | – | – | – |
| 1 (Hard) | x1 | – | 1 | – | – | +10% | +5% | – |
| 2 (Very hard) | x2 | – | 2 | – | +20% | +20% | +10% | – |
| 3 (Expert) | x2 | +1 | 3 | +1 | +40% | +40% | +10% | – |
| 4 (Nightmare) | x3 | +3 | 4 | +2 | +60% | +70% | +10% | Aggressive enemies |
| 5 (Hell) | x3 | +3 | 4 | +2 | +60% | +70% | +10% | Aggressive enemies, Malaise |