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Hungering Gaze · Slicing Maelstrom · Shadowfade · Ruin
Data from build 21587608, updated

Heretic
Unorthodoxy Risen
Transcendence converts all but 1 health into a regenerating shield and sets health regeneration to 0, which ends Heretic's drain. Hold all four Heresy items, then add Kjaro's and Runald's Bands so Ruin detonations and Maelstrom blasts trigger them.
Playing without a set build? The item tier list ranks every item against its own rarity, and those picks hold on any survivor.
Open the item tier list